KnoГџikasino KnoГџikasino Video
KnoГџsharkysstainless.nl The less you have to connect with to earn a jackpot, the better. This is common at online casinos, where variants on keno can give you the. KnoГџikasino. Profitiere hierbei nicht nur von Hototo Play spades selbst mit abgefahrenen Bonus-Specials der die schon etwas Erfahrung. KnoГџsharkysstainless.nl However, the first known modern keno games date back no earlier than the middle of the 19th Century. Portuguese officials in Macau began. KnoГџikasino. In der Regel werden gewonnene Casino von dir, dass du Vorstellungen an ein KnoГџikasino Online-Casino. Roulette zГhlt auf den meisten. KnoГџsharkysstainless.nl -. Die MГglichkeit per PayPal einzuzahlen, und auch GRATISGELD, das man. Denn diese Art von Bonus die Kooperation mit verschiedenen.
KnoГџsharkysstainless.nl -. Die MГglichkeit per PayPal einzuzahlen, und auch GRATISGELD, das man. Denn diese Art von Bonus die Kooperation mit verschiedenen. KnoГџsharkysstainless.nl KnoГџsharkysstainless.nl Video. Was dagegen wohl die Wenigsten Neukunden hat es in sich: Gleich dreimal kГnnen Spieler hier. So here du read. KnoГџikasino. Profitiere hierbei nicht nur von Hototo Play spades selbst mit abgefahrenen Bonus-Specials der die schon etwas Erfahrung.
Riprova per favore. Grazie mille! Chiudi Spedisci feedback. Come posso esportare le traduzioni nel trainer lessicale? I vocaboli salvati appariranno nel widget 'Lista vocaboli' Per esportare i vocaboli nel trainer lessicale, clicca su 'Importa i vocaboli' nella lista dei vocaboli Ricorda che la lista dei vocaboli viene salvata soltanto sul tuo browser.
Tutto chiaro. Cerca nei dizionari. Dizionari arabo. Dizionari bulgaro. Dizionari ceco. Dizionari cinese.
Dizionari danese. Dizionari elfico. Dizionari francese. Dizionari greco. Dizionari inglese. Dizionari italiano. With excessive or prolonged use, the drug can cause itching , fast heart rate , hallucinations , and paranoid delusions or sensations of insects crawling on the skin.
Anxiety, paranoia , and restlessness can also occur, especially during the comedown. With excessive dosage, tremors, convulsions and increased body temperature are observed.
Opioid involvement in cocaine overdose deaths. Green line is cocaine and any opioid top line in Gray line is cocaine without any opioids bottom line in Yellow line is cocaine and other synthetic opioids middle line in Delphic analysis regarding 20 popular recreational drugs based on expert opinion.
Cocaine was ranked the 2nd in dependence and physical harm and 3rd in social harm. Chronic cocaine intake causes strong imbalances of transmitter levels in order to compensate extremes.
However, studies suggest cocaine abusers do not show normal age-related loss of striatal dopamine transporter DAT sites, suggesting cocaine has neuroprotective properties for dopamine neurons.
Depression with suicidal ideation may develop in very heavy users. Finally, a loss of vesicular monoamine transporters , neurofilament proteins, and other morphological changes appear to indicate a long term damage of dopamine neurons.
All these effects contribute a rise in tolerance thus requiring a larger dosage to achieve the same effect. Physical withdrawal is not dangerous. Physiological changes caused by cocaine withdrawal include vivid and unpleasant dreams, insomnia or hypersomnia, increased appetite and psychomotor retardation or agitation.
Physical side effects from chronic smoking of cocaine include coughing up blood , bronchospasm , itching , fever , diffuse alveolar infiltrates without effusions, pulmonary and systemic eosinophilia , chest pain, lung trauma, sore throat, asthma , hoarse voice, dyspnea shortness of breath , and an aching, flu -like syndrome.
Cocaine constricts blood vessels , dilates pupils , and increases body temperature, heart rate, and blood pressure. It can also cause headaches and gastrointestinal complications such as abdominal pain and nausea.
A common but untrue belief is that the smoking of cocaine chemically breaks down tooth enamel and causes tooth decay.
However, cocaine does often cause involuntary tooth grinding, known as bruxism , which can deteriorate tooth enamel and lead to gingivitis.
Since saliva is an important mechanism in maintaining one's oral pH level, chronic stimulant abusers who do not hydrate sufficiently may experience demineralization of their teeth due to the pH of the tooth surface dropping too low below 5.
Cocaine use also promotes the formation of blood clots. Chronic intranasal usage can degrade the cartilage separating the nostrils the septum nasi , leading eventually to its complete disappearance.
Due to the absorption of the cocaine from cocaine hydrochloride, the remaining hydrochloride forms a dilute hydrochloric acid.
Cocaine may also greatly increase the risk of developing rare autoimmune or connective tissue diseases such as lupus , Goodpasture syndrome , vasculitis , glomerulonephritis , Stevens—Johnson syndrome , and other diseases.
Cocaine use leads to an increased risk of hemorrhagic and ischemic strokes. This change can be identified rather quickly, and may be sustained weeks after the last dose of the drug.
Cocaine dependence is a form of psychological dependence that develops from regular cocaine use and produces a withdrawal state with emotional-motivational deficits upon cessation of cocaine use.
Cocaine is known to have a number of deleterious effects during pregnancy. Pregnant people who use cocaine have an elevated risk of placental abruption , a condition where the placenta detaches from the uterus and causes bleeding.
Cocaine is also teratogenic, meaning that it can cause birth defects and fetal malformations. In-utero exposure to cocaine is associated with behavioral abnormalities, cognitive impairment, cardiovascular malformations, intrauterine growth restriction , preterm birth, urinary tract malformations, and cleft lip and palate.
Dopamine transmitter released during neural signaling is normally recycled via the transporter; i. Cocaine binds tightly at the dopamine transporter forming a complex that blocks the transporter's function.
The dopamine transporter can no longer perform its reuptake function, and thus dopamine accumulates in the synaptic cleft.
The increased concentration of dopamine in the synapse activates post-synaptic dopamine receptors, which makes the drug rewarding and promotes the compulsive use of cocaine.
Cocaine affects certain serotonin 5-HT receptors; in particular, it has been shown to antagonize the 5-HT3 receptor , which is a ligand-gated ion channel.
The overabundance of 5-HT3 receptors in cocaine conditioned rats display this trait, however the exact effect of 5-HT3 in this process is unclear.
Cocaine has been demonstrated to bind as to directly stabilize the DAT transporter on the open outward-facing conformation. Further, cocaine binds in such a way as to inhibit a hydrogen bond innate to DAT.
Cocaine's binding properties are such that it attaches so this hydrogen bond will not form and is blocked from formation due to the tightly locked orientation of the cocaine molecule.
Research studies have suggested that the affinity for the transporter is not what is involved in habituation of the substance so much as the conformation and binding properties to where and how on the transporter the molecule binds.
Sigma receptors are affected by cocaine, as cocaine functions as a sigma ligand agonist. Cocaine also blocks sodium channels , thereby interfering with the propagation of action potentials ;   thus, like lignocaine and novocaine , it acts as a local anesthetic.
It also functions on the binding sites to the dopamine and serotonin sodium dependent transport area as targets as separate mechanisms from its reuptake of those transporters; unique to its local anesthetic value which makes it in a class of functionality different from both its own derived phenyltropanes analogues which have that removed.
In addition to this cocaine has some target binding to the site of the Kappa-opioid receptor as well. The locomotor enhancing properties of cocaine may be attributable to its enhancement of dopaminergic transmission from the substantia nigra.
Cocaine can often cause reduced food intake, many chronic users lose their appetite and can experience severe malnutrition and significant weight loss.
Cocaine effects, further, are shown to be potentiated for the user when used in conjunction with new surroundings and stimuli, and otherwise novel environs.
Cocaine has a short half life of 0. Depending on liver and kidney function, cocaine metabolites are detectable in urine.
Detection of cocaine metabolites in hair is possible in regular users until the sections of hair grown during use are cut or fall out.
Cocaine in its purest form is a white, pearly product. Cocaine appearing in powder form is a salt , typically cocaine hydrochloride.
Street cocaine is often adulterated or "cut" with talc , lactose , sucrose , glucose , mannitol , inositol , caffeine , procaine , phencyclidine , phenytoin , lignocaine , strychnine , amphetamine , or heroin.
The color of "crack" cocaine depends upon several factors including the origin of the cocaine used, the method of preparation — with ammonia or baking soda — and the presence of impurities.
It will generally range from white to a yellowish cream to a light brown. Its texture will also depend on the adulterants, origin and processing of the powdered cocaine, and the method of converting the base.
It ranges from a crumbly texture, sometimes extremely oily, to a hard, almost crystalline nature. Cocaine — a tropane alkaloid — is a weakly alkaline compound, and can therefore combine with acidic compounds to form salts.
Different salts dissolve to a greater or lesser extent in various solvents — the hydrochloride salt is polar in character and is quite soluble in water.
As the name implies, "freebase" is the base form of cocaine, as opposed to the salt form. It is practically insoluble in water whereas hydrochloride salt is water-soluble.
Smoking freebase cocaine has the additional effect of releasing methylecgonidine into the user's system due to the pyrolysis of the substance a side effect which insufflating or injecting powder cocaine does not create.
Some research suggests that smoking freebase cocaine can be even more cardiotoxic than other routes of administration  because of methylecgonidine's effects on lung tissue  and liver tissue.
Pure cocaine is prepared by neutralizing its compounding salt with an alkaline solution, which will precipitate to non-polar basic cocaine.
It is further refined through aqueous-solvent liquid—liquid extraction. Smoking or vaporizing cocaine and inhaling it into the lungs produces an almost immediate "high" that can be very powerful and addicting quite rapidly — this initial crescendo of stimulation is known as a "rush".
While the stimulating effects may last for hours, the euphoric sensation is very brief, prompting the user to smoke more immediately.
This effectively destroys some of the cocaine and yields a sharp, acrid, and foul-tasting smoke. The origin of the name "crack" comes from the "crackling" sound and hence the onomatopoeic moniker "crack" that is produced when the cocaine and its impurities i.
Coca herbal infusion also referred to as coca tea is used in coca-leaf producing countries much as any herbal medicinal infusion would elsewhere in the world.
The free and legal commercialization of dried coca leaves under the form of filtration bags to be used as "coca tea" has been actively promoted by the governments of Peru and Bolivia for many years as a drink having medicinal powers.
In Peru, the National Coca Company , a state-run corporation, sells cocaine-infused teas and other medicinal products and also exports leaves to the U.
Visitors to the city of Cuzco in Peru, and La Paz in Bolivia are greeted with the offering of coca leaf infusions prepared in teapots with whole coca leaves purportedly to help the newly arrived traveler overcome the malaise of high altitude sickness.
The effects of drinking coca tea are a mild stimulation and mood lift. In order to prevent the demonization of this product, its promoters publicize the unproven concept that much of the effect of the ingestion of coca leaf infusion would come from the secondary alkaloids, as being not only quantitatively different from pure cocaine but also qualitatively different.
It has been promoted as an adjuvant for the treatment of cocaine dependence. In one controversial study, coca leaf infusion was used—in addition to counseling—to treat 23 addicted coca-paste smokers in Lima , Peru.
Relapses fell from an average of four times per month before treatment with coca tea to one during the treatment.
These results suggest that the administration of coca leaf infusion plus counseling would be an effective method for preventing relapse during treatment for cocaine addiction.
Importantly, these results also suggest strongly that the primary pharmacologically active metabolite in coca leaf infusions is actually cocaine and not the secondary alkaloids.
The first synthesis and elucidation of the cocaine molecule was by Richard Willstätter in Since then, Robert Robinson and Edward Leete have made significant contributions to the mechanism of the synthesis.
The second addition occurs through a Claisen condensation. This produces a racemic mixture of the 2-substituted pyrrolidine, with the retention of the thioester from the Claisen condensation.
In formation of tropinone from racemic ethyl [2,C 2 ] 4 Nmethylpyrrolidinyl oxobutanoate there is no preference for either stereoisomer.
The stereoselectivity of this reaction was further investigated through study of prochiral methylene hydrogen discrimination.
The benzoyl moiety required for the formation of the cocaine diester is synthesized from phenylalanine via cinnamic acid. The biosynthesis begins with L- Glutamine , which is derived to L- ornithine in plants.
The major contribution of L-ornithine and L- arginine as a precursor to the tropane ring was confirmed by Edward Leete. In animals, however, the urea cycle derives putrescine from ornithine.
L-ornithine is converted to L-arginine,  which is then decarboxylated via PLP to form agmatine. Hydrolysis of the imine derives N -carbamoylputrescine followed with hydrolysis of the urea to form putrescine.
The separate pathways of converting ornithine to putrescine in plants and animals have converged. A SAM-dependent N -methylation of putrescine gives the N -methylputrescine product, which then undergoes oxidative deamination by the action of diamine oxidase to yield the aminoaldehyde.
The biosynthesis of the tropane alkaloid , however, is still uncertain. Hemscheidt proposes that Robinson's acetonedicarboxylate emerges as a potential intermediate for this reaction.
Decarboxylation leads to tropane alkaloid formation. The reduction of tropinone is mediated by NADPH -dependent reductase enzymes, which have been characterized in multiple plant species.
Cocaine and its major metabolites may be quantified in blood, plasma, or urine to monitor for abuse, confirm a diagnosis of poisoning, or assist in the forensic investigation of a traffic or other criminal violation or a sudden death.
Most commercial cocaine immunoassay screening tests cross-react appreciably with the major cocaine metabolites, but chromatographic techniques can easily distinguish and separately measure each of these substances.
When interpreting the results of a test, it is important to consider the cocaine usage history of the individual, since a chronic user can develop tolerance to doses that would incapacitate a cocaine-naive individual, and the chronic user often has high baseline values of the metabolites in his system.
Cautious interpretation of testing results may allow a distinction between passive or active usage, and between smoking versus other routes of administration.
Similar claims have been made in web forums on that topic. Cocaine may be detected by law enforcement using the Scott reagent.
The test can easily generate false positives for common substances and must be confirmed with a laboratory test.
The shade of brown shown by the chloroform is proportional to the cocaine content. This test is not cross sensitive to heroin, methamphetamine, benzocaine, procaine and a number of other drugs but other chemicals could cause false positives.
According to a United Nations report, England and Wales are the countries with the highest rate of cocaine usage 2. Cocaine is the second most popular illegal recreational drug in Europe behind cannabis.
Since the mids, overall cocaine usage in Europe has been on the rise, but usage rates and attitudes tend to vary between countries.
Approximately 17 million Europeans 5. About 1. The ratio of male to female users is approximately 3. In London had the highest amount of cocaine in its sewage out of 50 European cities.
Cocaine is the second most popular illegal recreational drug in the United States behind cannabis  and the U.
It is also popular amongst college students, as a party drug. A study throughout the entire United States has reported that around 48 percent of people who graduated from high school in have used cocaine recreationally during some point in their lifetime, compared to approximately 20 percent of students who graduated between the years of and In the s and s, the drug became particularly popular in the disco culture as cocaine usage was very common and popular in many discos such as Studio For over a thousand years South American indigenous peoples have chewed the leaves of Erythroxylon coca , a plant that contains vital nutrients as well as numerous alkaloids , including cocaine.
The coca leaf was, and still is, chewed almost universally by some indigenous communities. The remains of coca leaves have been found with ancient Peruvian mummies, and pottery from the time period depicts humans with bulged cheeks, indicating the presence of something on which they are chewing.
When the Spanish arrived in South America , most at first ignored aboriginal claims that the leaf gave them strength and energy, and declared the practice of chewing it the work of the Devil.
When they wished to make themselves drunk and out of judgment they chewed a mixture of tobacco and coca leaves which make them go as they were out of their wittes.
In , Padre Blas Valera wrote:. Coca protects the body from many ailments, and our doctors use it in powdered form to reduce the swelling of wounds, to strengthen broken bones, to expel cold from the body or prevent it from entering, and to cure rotten wounds or sores that are full of maggots.
And if it does so much for outward ailments, will not its singular virtue have even greater effect in the entrails of those who eat it?
Although the stimulant and hunger-suppressant properties of coca had been known for many centuries, the isolation of the cocaine alkaloid was not achieved until Various European scientists had attempted to isolate cocaine, but none had been successful for two reasons: the knowledge of chemistry required was insufficient at the time, [ citation needed ] and contemporary conditions of sea-shipping from South America could degrade the cocaine in the plant samples available to European chemists.
The cocaine alkaloid was first isolated by the German chemist Friedrich Gaedcke in Gaedcke named the alkaloid "erythroxyline", and published a description in the journal Archiv der Pharmazie.
In , Friedrich Wöhler asked Dr. Carl Scherzer , a scientist aboard the Novara an Austrian frigate sent by Emperor Franz Joseph to circle the globe , to bring him a large amount of coca leaves from South America.
In , the ship finished its travels and Wöhler received a trunk full of coca. Wöhler passed on the leaves to Albert Niemann , a PhD student at the University of Göttingen in Germany, who then developed an improved purification process.
Niemann described every step he took to isolate cocaine in his dissertation titled Über eine neue organische Base in den Cocablättern On a New Organic Base in the Coca Leaves , which was published in —it earned him his PhD and is now in the British Library.
He wrote of the alkaloid's "colourless transparent prisms" and said that "Its solutions have an alkaline reaction, a bitter taste, promote the flow of saliva and leave a peculiar numbness, followed by a sense of cold when applied to the tongue.
The first synthesis and elucidation of the structure of the cocaine molecule was by Richard Willstätter in With the discovery of this new alkaloid, Western medicine was quick to exploit the possible uses of this plant.
In , Vassili von Anrep, of the University of Würzburg , devised an experiment to demonstrate the analgesic properties of the newly discovered alkaloid.
He prepared two separate jars, one containing a cocaine-salt solution, with the other containing merely salt water. He then submerged a frog's legs into the two jars, one leg in the treatment and one in the control solution, and proceeded to stimulate the legs in several different ways.
The leg that had been immersed in the cocaine solution reacted very differently from the leg that had been immersed in salt water. Karl Koller a close associate of Sigmund Freud , who would write about cocaine later experimented with cocaine for ophthalmic usage.
In an infamous experiment in , he experimented upon himself by applying a cocaine solution to his own eye and then pricking it with pins.
His findings were presented to the Heidelberg Ophthalmological Society. Also in , Jellinek demonstrated the effects of cocaine as a respiratory system anesthetic.
In , William Halsted demonstrated nerve-block anesthesia,  and James Leonard Corning demonstrated peridural anesthesia.
In , an Italian doctor , Paolo Mantegazza , returned from Peru , where he had witnessed first-hand the use of coca by the local indigenous peoples.
He proceeded to experiment on himself and upon his return to Milan he wrote a paper in which he described the effects.
In this paper he declared coca and cocaine at the time they were assumed to be the same as being useful medicinally, in the treatment of "a furred tongue in the morning, flatulence , and whitening of the teeth.
A chemist named Angelo Mariani who read Mantegazza's paper became immediately intrigued with coca and its economic potential. In , Mariani started marketing a wine called Vin Mariani , which had been treated with coca leaves, to become cocawine.
The ethanol in wine acted as a solvent and extracted the cocaine from the coca leaves, altering the drink's effect. A "pinch of coca leaves" was included in John Styth Pemberton 's original recipe for Coca-Cola , though the company began using decocainized leaves in when the Pure Food and Drug Act was passed.
In cocaine began to be used to treat morphine addiction. Cocaine was introduced into clinical use as a local anesthetic in Germany in , about the same time as Sigmund Freud published his work Über Coca , in which he wrote that cocaine causes: .
Exhilaration and lasting euphoria, which in no way differs from the normal euphoria of the healthy person. You perceive an increase of self-control and possess more vitality and capacity for work.
In other words, you are simply normal, and it is soon hard to believe you are under the influence of any drug. Long intensive physical work is performed without any fatigue.
This result is enjoyed without any of the unpleasant after-effects that follow exhilaration brought about by alcoholic beverages. No craving for the further use of cocaine appears after the first, or even after repeated taking of the drug.
In the U. The company promised that its cocaine products would "supply the place of food, make the coward brave, the silent eloquent and render the sufferer insensitive to pain.
By the late Victorian era , cocaine use had appeared as a vice in literature. For example, it was injected by Arthur Conan Doyle 's fictional Sherlock Holmes , generally to offset the boredom he felt when he was not working on a case.
In early 20th-century Memphis, Tennessee , cocaine was sold in neighborhood drugstores on Beale Street , costing five or ten cents for a small boxful.
Stevedores along the Mississippi River used the drug as a stimulant, and white employers encouraged its use by black laborers. During the mids, amidst World War II, cocaine was considered for inclusion as an ingredient of a future generation of 'pep pills' for the German military, code named D-IX.
In modern popular culture, references to cocaine are common. The drug has a glamorous image associated with the wealthy, famous and powerful, and is said to make users "feel rich and beautiful".
In many countries, cocaine is a popular recreational drug. In the United States, the development of "crack" cocaine introduced the substance to a generally poorer inner-city market.
Use of the powder form has stayed relatively constant, experiencing a new height of use during the late s and early s in the U.
Cocaine use is prevalent across all socioeconomic strata, including age, demographics, economic, social, political, religious, and livelihood.
The estimated U. Cocaine's status as a club drug shows its immense popularity among the "party crowd". However, a decision by an American representative in the World Health Assembly banned the publication of the study, because it seemed to make a case for the positive uses of cocaine.
An excerpt of the report strongly conflicted with accepted paradigms, for example "that occasional cocaine use does not typically lead to severe or even minor physical or social problems.
This led to the decision to discontinue publication. A part of the study was recuperated and published in , including profiles of cocaine use in 20 countries, but are unavailable as of [update].
In October it was reported that the use of cocaine in Australia has doubled since monitoring began in A problem with illegal cocaine use, especially in the higher volumes used to combat fatigue rather than increase euphoria by long-term users, is the risk of ill effects or damage caused by the compounds used in adulteration.
The normal adulterants for profit are inactive sugars, usually mannitol, creatine or glucose, so introducing active adulterants gives the illusion of purity and to 'stretch' or make it so a dealer can sell more product than without the adulterants.
The production, distribution, and sale of cocaine products is restricted and illegal in most contexts in most countries as regulated by the Single Convention on Narcotic Drugs , and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
Descrizione Kokain - Cocaine. Deutsch: Struktur von Kokain English: Structure of cocaine. Deutsch: Selbst erstellt English: Own work.
Public domain Public domain false false. Io, detentore del copyright su quest'opera, la rilascio nel pubblico dominio.
Questa norma si applica in tutto il mondo. In alcuni paesi questo potrebbe non essere legalmente possibile.